Principles of use of antibacterial agents.

The selection of an antimicrobial regimen is based on a number of factors, including the nature of the infection, the identity and susceptibility of the pathogens, host characteristics, and the pharmacokinetics and pharmacodynamics of antimicrobial agents. This article provides a comprehensive overview of these factors, with particular attention to pharmacokinetics and monitoring for efficacy and toxicity. A brief summary is also provided of some other topics discussed in detail elsewhere in this issue, such as susceptibility testing, pharmacodynamics, and pharmacokinetics-pharmacodynamics parameters.